TCUP uses peptides generated by mass spectrometry proteomics to:
- identify and estimate the taxonomic composition of a microbial sample.
- detect expressed antibiotic resistance proteins.
TCUP does not require a priori information about the contents of a sample and is suitable for analysis of both pure cultures, mixed samples, and clinical samples.
Read Introduction and overview for more details on how it works. If you prefer to throw yourself head-first into TCUP without first knowing the details of how it works, check out Installation right away to get started!
This is the documentation for TCUP version 1.1.0, last updated Sep 06, 2022. The documentation is available online at
TCUP is published as open-source under the ISC license and you are welcome to look at, suggest improvements, or download and improve/contribute to the code at the project’s Bitbucket page.
If you find TCUP useful, please cite the following paper that describes the method:
- Introduction and overview
- Preparing databases for use with TCUP
- Running TCUP
- Example output